Monday, June 11, 2012

Genetics Home Reference: dystonia l-dopa unresponsive

L-dopa unresponsive dystonia is a disorder that involves involuntary contractions of muscles, tremors, and other uncontrolled movements (dystonia). Features of this condition range from mild to severe. This form of dystonia is called l-dopa responsive dystonia, since the signs and symptoms usually increase sustainable use of drugs known as l-dopa.

The signs and symptoms of l-dopa unresponsive dystonia usually appear during childhood, usually around the age of 6. The first signs of the State are usually the development-and upwards-return rates (clubfeet) and dystonia in amputation. Dystonia spreads on hand at the time; beginning in adolescence, the whole body is usually involved. People affected by the disease may have abnormal limb positioning and lack of coordination during walking or running. Some people with this condition have problems with sleep or episodes of depression more often than normally expected.

Over time, the people affected by the disease often develop group is the irregularity of movement called Parkinsonism. These abnormalities include unusually slow movement (bradykinesia), rigidity, tremors and inability to hold the body upright and balanced (postural instability).

Movement difficulties related to l-dopa unresponsive dystonia usually worsen with age, but to stabilize around the age of 30. Characteristic feature of l-dopa unresponsive dystonia is worsening the problems flow later in the day and the improvement of symptoms in the morning after sleep (diurnal fluctuations).

Rarely flow problems related to l-dopa unresponsive dystonia do not appear until adulthood. In such cases of adult onset Parkinsonism usually develops before the dystonia, and movement problems are slowly increasing, and do not Show diurnal fluctuations.

L-dopa unresponsive dystonia is estimated at 1 million people around the world. However, the disorder is likely under diagnosed because the condition may not be identified in people with mild symptoms, or may be Misdiagnosed in people who are similar to other treat disorders symptoms.

A mutation of the gene GCH1 is the most common cause of dystonia l-dopa unresponsive. Rarely a mutation of the gene TH or SPR cause this condition.

Gen GCH1 instructions for making the enzyme called GTP cyclohydrolase. The enzyme is involved in the first of the three stages of production of a molecule called tetrahydrobiopterin (BH4). Gene SPR instructions for making the enzyme sepiapterin reductase, is engaged in the last stage of the production of tetrahydrobiopterin. Tetrahydrobiopterin helps you process several protein building blocks (amino acids) and is involved in the production of chemical substances called neurotransmitters that transmit signals between neurons in the brain. In particular, tetrahydrobiopterin is engaged in the production of two neurotransmitters called dopamine and serotoniny. Among the many functions of dopamine transmits signals in the brain to produce smooth physical movements and serotoniny regulates mood, emotion, sleep and appetite.

The protein produced from the gene TH. is also involved in the production of dopamine. The gene for tryptophan hydroxylase enzyme TH instructions, which helps you convert the amino acid tyrosine dopamine.

A mutation of the gene GCH1, or SPR interfere with production of tetrahydrobiopterin, which leads to a reduction in the amount of dopamine available. In the production of the enzyme tyrosine hydroxylase function reduced, leading to a reduction in the production of dopamine by TH mutation. Reduction in the amount of dopamine to interfere with the ability of the brain to produce smooth physical movements, dystonia, tremor and other problems flow associated with dystonia l-dopa unresponsive. Disorders of sleep and mood also occur in some people with GCH1 or SPR gene mutations; such disorders may result from interference in the production of serotoniny. Problems with sleep and episodes of depression are not visible in people with l-dopa unresponsive dystonia due to TH mutation, which is sometimes referred to as the band Segawa.

Some people with l-dopa unresponsive dystonia has identified mutations in the GCH1, cz, or SPR gene. Status reason in these people is unknown.

Learn more about genes GCH1, SPR and GREN.

When l-dopa unresponsive dystonia is caused by a mutation of the gene GCH1, is inherited autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to disorder. In some cases, the affected person inherits a mutation affected parent. Other cases arising from new mutations in the gene and occur in people history of the disorder in their family.

Some people who will inherit the changed gene GCH1 never expands features of dystonia l-dopa unresponsive. (This situation is known as a reduced penetrance). It is not clear Why some people with the mutated gene is the development of the disease, not the other people of the mutated gene. For unknown reasons correspond to l-dopa dystonia due to mutation of the gene GCH1 concerns females two to four times more often than males.

When TH mutations are responsible for causing l-dopa unresponsive dystonia, is inherited autosomal recessive pattern, which means both copies of the gene in each cell mutation. Autosomal recessive condition of the parents who each carry one copy of the mutated gene, but usually do not show signs and symptoms of the condition.

When l-dopa unresponsive dystonia is caused by a mutation of the gene SPR, may have autosomal recessive or, more rarely, autosomal dominant pattern of inheritance.

These resources Address the diagnosis or management of l-dopa unresponsive dystonia and may include treatment of suppliers.

You can also learn about the diagnosis or management of l-dopa unresponsive dystonia educational resources and support to patients.

To locate a provider of health care, see how do I find a genetics professional in my area? in the manual.

The following resources with l-dopa unresponsive dystonia may find useful. These materials are written for the general public.

Can also be interested in these resources, which are intended for health professionals and researchers.

Dystonia progressive with diurnal fluctuations marked DRDhereditary

For more information about names, see genetics Genetics Home Reference condition names guidelines and how genetic conditions and genes called? in the manual.

The manual contains basic information about genetics in clear language.

These links provide additional resources of modern genetics, which may be useful.

The resources on this page should not be used as a substitute for professional medical care or advice. Users seeking personal information of genetic disease, syndrome or condition, consult with a qualified professional care. See how you can find a genetics professional in my area? in the manual.


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